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cheapbag214s · Posted: Thu 5:51, 07 Nov 2013 Post subject: cholesterol-25-hydroxylase

Newly identified protein blocks HIV, other deadly viruses
LOS ANGELES, Feb. 14 () -- U.S. researchers say they identified a protein with broad virus-fighting properties that potentially could be used as a weapon viruses such as HIV and Ebola. Su-Yang Liu, a student, and Genhong Cheng, a professor at the David Geffen School of Medicine at the University of California, Los Angeles, said the novel anti-viral property of the protein, cholesterol-25-hydroxylase, is an enzyme that converts cholesterol to an oxysterol called 25-hydroxycholesterol, which can permeate a cell's wall and block a virus from entering. The cholesterol-25-hydroxylase enzyme is activated by interferon, an essential antiviral cell-signaling protein produced in the body, the researchers said. "Anti-viral genes have been hard to apply for therapeutic purposes because it is difficult to express genes in cells," Liu said in a statement. "Cholesterol-25-hydroxylase produces a natural,[url=http://www.outletonliner.com]hemers outlet online[/url], soluble oxysterol that can be synthesized and administered. Also, our initial studies showing that 25HC can inhibit HIV growth in vivo should prompt further study into membrane-modifying cholesterols that inhibit viruses."The discovery is particularly relevant to efforts to develop broad-spectrum antivirals against an increasing number of emerging viral pathogens,[url=http://www.christianlouboutin-vips.com/]Christian Louboutin Discount[/url], Liu said. The findings were published in the journal Immunity.